The Role of Aspartame sweetner in Instant Beverages in Inducing Gross Malformations and Histpathological Lesions in White Mice Liver Mus musculs and Their Embryos

The present study was made to investigate the role of high doses aspartame used as sweeteners instant beverages (Tropicana Slim) for inducing gross malformations and histopathological lesions in liver white mice their embryos, furthermore embryos these mice. For this purpose (25) pregnant were which divided into five equal groups (one control four experimental groups). Aspartame given single daily dose a concentration (0,1500, 2500, 3500, 5000) mg/Kg body weight (b. w.). At 1500 mg/Kg, there closure left eye death some In 3500 (b.w.), abortion seen 20% well vaginal bleeding at 10th day pregnancy. pale, greenish with appearance fatty substance appeared. Microscopically, dilatation sinusoids, degenerative necrotic change hepatocyts, fibrin deposition, apoptosis, Kupffer cell hypertrophy, occurred rate 84% main congenital detects induced curved hyperatrophied hypertrophy brain, rounded head bird peak-like appearance, groove separate small from body, meningomsclocele, spina bifida, chortening curvature extremities, tail that looks like question mark. histological similar mothers